Methylcobalamin: A Potential Vitamin of Pain Killer

Table 1

The analgesic effect of MeCbl or combined use with other drugs on patients with diabetic neuropathic pain.

Effects of MeCbl	Indices	Measures of intervention	Reference
Alleviation of neuropathic pain symptoms; improved nerve conduction velocity	Pain scale scores of patients; measure of nerve conduction velocity	Oral administration of MeCbl for 3 months	Devathasan et al. [12]
Improved nerve conduction velocity	Measure of nerve conduction velocity	Intravenous administration of MeCbl	Ishihara et al. [14]
Improved the symptoms of paresthesia, burning pains, and heaviness; no effect on nerve conduction velocity	Pain symptoms; measure of nerve conduction velocity	Repeated intrathecal injection of MeCbl at a high dose of 2.5 mg/10 mL	Ide et al. [21]
Relieved spontaneous pain by 73%	Likert-type pain intensity scale; Patients’ Global Impression of Change (PGIC) scale	Intramuscular injection of MeCbl for four weeks followed by oral administration of MeCbl for additional eight weeks	Li [22]
Relieved pain and paresthesia; improved motor and sensory nerve conduction velocity	Neurolgical disability score for the grades of pain and paresthesia	Intravenous injection of MeCbl for 6 weeks	Kuwabara et al. [13]
Reduced pain scores and good tolerance	Visual analog scale and chemical safety	Oral administration of immediate-release methylcobalamin and sustained-release pregabalin for 2 weeks.	Dongre and Swami [23]