Methylcobalamin: A Potential Vitamin of Pain Killer

Table 2

The analgesic effects of MeCbl on low back pain and neck pain in clinical trials.

Effects of MeCbl	Indices	Measures of intervention	Reference
Relieved spontaneous pain, allodynia, and paresthesia.	Pain symptoms of patients with neck pain	Oral administration of MeCbl for 4 weeks	Hanai et al. [29]
Amelioration of neurogenic claudication distance; no effect on pain improvement and neurological signs	Pain symptoms; measure the neurogenic claudication distance of patients with degenerative lumbar spinal stenosis	Oral administration of MeCbl as an adjuvant medication for 6 months	W. Waikakul and S. Waikakul [25]
Reduced pain	Oswestry disability index questionnaire (ODI) and visual analogue scale (VAS) pain score of patients with nonspecific low back pain	Intramuscular injection of MeCbl for 2 weeks	Chiu et al. [26]