Odorant Receptors Signaling Instructs the Development and Plasticity of the Glomerular Map

Figure 5

Chronic exposure to pure acetophenone influences the formation of M72tLacZ glomeruli in the OB. (a) A lateral M72 glomerulus in one OB of a 20-day-old M72tLacZ mouse. Typically, only one lateral glomerulus is formed in all mice. (b) Formation of M72 supernumerary glomeruli after 20 days of acetophenone exposure from birth. (c) Regeneration of lateral M72 glomeruli in both OBs in a M72tLacZ adult mouse 45 days after methimazole treatment. (d) Dispersed and mistargeted M72 axons with no glomerular formation in an adult mouse exposed to acetophenone for 35 days after methimazole treatment (days 10–45).

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