Review Article
The Role of fMRI in the Assessment of Neuroplasticity in MS: A Systematic Review
Table 5
Longitudinal r-fMRI papers.
| Authors (year) | Sample size | Age at baseline (mean) | MS duration (years) | EDSS (median) | Technique(s) | Follow-up | Functional main result(s) | Clinical correlation(s) | Structural correlation(s) |
| Droby et al. (2016) [72] | 9 RR | 42.3 (9.2) | 6.2 (8.0) 1.0 (0.3) | | Seed (left precuneus) | 5 bimonthly follow-up periods | Higher FC in MS with periventricular lesion in the cuneus and precuneus regions No changes in FC over time in clinically stable RR | — | — | Faivre et al. (2016) [73] | 38 RR 24 HS | 36.1 (5.1) 33.1 (6.4) | 10.0 (2.7) — | 1.0 [0.0–6.5] — | Graph theory | 2 years | Connectivity metric increment in not disabled and decrement in disabled MS | Correlation between decrease in connectivity metrics and disability progression | No significant results |
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Italic font: mean; round parenthesis: standard deviation; squared parenthesis: range.
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