|
| Q1 | Q2 | Q3 | Q4 | Q5 | Q6 | Q7 | Q8 | Q9 | Q10 | TOT |
|
t-fMRI cross-sectional | | | | | | | | | | | |
Sensorimotor | | | | | | | | | | | |
Reddy et al. (2000) [22] | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 4 |
Filippi et al. (2002) [16] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 4 |
Pantano et al. (2002) [19] | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 6 |
Reddy et al. (2002) [13] | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 7 |
Pantano et al. (2002) [8] | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 6 |
Rocca et al. (2002) [17] | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 5 |
Rocca et al. (2003) [14] | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 3 |
Rocca et al. (2003) [9] | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 6 |
Rocca et al. (2003) [80] | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 5 |
Filippi et al. (2004) [12] | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 4 |
Filippi et al. (2004) [86] | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 6 |
Rocca et al. (2005) [20] | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 6 |
Ciccarelli et al. (2006) [18] | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 7 |
Wang and Hier (2007) [87] | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 4 |
Wegner et al. (2008) [88] | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 6 |
Rocca et al. (2009) [79] | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 7 |
Harirchian et al. (2010) [10] | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 4 |
Rocca et al. (2010) [15] | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 8 |
Rico et al. (2011) [11] | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 3 |
Petsas et al. (2013) [21] | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 8 |
Faivre et al. (2015) [89] | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 7 |
Cognitive | | | | | | | | | | | |
Staffen et al. (2002) [23] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 |
Audoin et al. (2003) [24] | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 5 |
Penner et al. (2003) [45] | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 4 |
Mainero et al. (2004) [26] | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 6 |
Saini et al. (2004) [90] | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 6 |
Audoin et al. (2005) [25] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 4 |
Cader et al. (2006) [31] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 8 |
Forn et al. (2006) [27] | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Rachbauer et al. (2006) [28] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 |
Sweet et al. (2006) [32] | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 6 |
Forn et al. (2007) [33] | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3 |
Morgen et al. (2007) [42] | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 8 |
Nebel et al. (2007) [91] | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 4 |
Prakash et al. (2007) [29] | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 6 |
Prakash et al. (2008) [43] | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 7 |
Bonzano et al. (2009) [30] | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 3 |
Passamonti et al. (2009) [44] | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 5 |
Pierno et al. (2009) [92] | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 6 |
Rocca et al. (2009) [81] | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 8 |
Smith et al. (2010) [93] | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 5 |
Bonnet et al. (2010) [40] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 6 |
Helekar et al. (2010) [94] | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 6 |
Rocca et al. (2010) [34] | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 7 |
Amann et al. (2011) [35] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 5 |
Jehna et al. (2011) [95] | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 7 |
Loitfelder et al. (2011) [41] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 8 |
Colorado et al. (2012) [96] | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 8 |
Hulst et al. (2012) [38] | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 4 |
Kern et al. (2012) [39] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 8 |
Smith et al. (2012) [97] | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3 |
Forn et al. (2013) [96] | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 7 |
Rocca et al. (2014) [36] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 8 |
Weygandt et al. (2017) [37] | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 6 |
Tacchino et al. (2018) [99] | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 7 |
t-fMRI longitudinal | | | | | | | | | | | |
Pantano et al. (2005) [46] | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 5 |
Mezzapesa et al. (2008) [47] | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 5 |
Audoin et al. (2008) [48] | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 7 |
Pantano et al. (2011) [100] | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 8 |
Loitfelder et al. (2014) [101] | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 7 |
t-fMRI Interventional | | | | | | | | | | | |
Parry et al. (2003) [49] | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 7 |
Mainero et al. (2004) [50] | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 4 |
Morgen et al. (2004) [52] | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 5 |
Rasova et al. (2005) [102] | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 5 |
Sastre-Garriga et al. (2011) [54] | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 3 |
Cerasa et al. (2013) [53] | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 7 |
Ernst et al. (2012) [55] | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 5 |
Tomassini et al. (2012) [2] | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 7 |
Hubacher et al. (2015) [56] | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 4 |
Tomassini al. (2016) [51] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 7 |
Leonard et al. (2017) [103] | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 4 |
r-fMRI cross-sectional | | | | | | | | | | | |
Roosendaal et al. (2010) [60] | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 6 |
Bonavita et al. (2011) [63] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 7 |
Liu et al. (2011) [58] | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 6 |
Faivre et al. (2012) [61] | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 7 |
Liu et al. (2012) [57] | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 7 |
Gallo et al. (2012) [65] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 8 |
Rocca et al. (2010) [83] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 10 |
Schoonheim et al. (2012) [62] | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 6 |
Schoonheim al. (2014) [71] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 9 |
Tona et al. (2014) [67] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 8 |
Zhou et al. (2014) [59] | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 8 |
Liu et al. (2015) [68] | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 7 |
Liu et al. (2016) [66] | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 6 |
Rocca et al. (2016) [70] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 10 |
Zhong et al. (2016) [69] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 10 |
Bisecco et al. (2017) [64] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 9 |
r-fMRI longitudinal | | | | | | | | | | | |
Droby et al. (2015) [72] | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 5 |
Faivre et al. (2016) [73] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 8 |
r-fMRI interventional | | | | | | | | | | | |
Filippi et al. (2012) [75] | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 6 |
Petsas et al. (2014) [74] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 10 |
Boutiere et al. (2016) [77] | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 6 |
De Giglio et al. (2016) [76] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 8 |
Methodology | Q1: Were a priori hypotheses clearly stated? |
Q2: Was the sample size equal to or larger than 30 subjects? |
Clinical characteristics | Q3: Was MS phenotype included? |
Q4: Was clinical information, e.g., relapses and/or treatment, reported? |
MRI parameters | Q5: Was the used MRI filed equal to or greater than 3T? |
Statistical analysis | Q6: Was correction for multiple comparison used? |
Q7: Were covariates of no interest included in the analysis? |
Results | Q8: Were correlations between fMRI outcomes and clinical scores investigated? |
Q9: Were correlations between fMRI outcomes and structural measures investigated? |
Q10: Were limitations of the study clearly stated? |
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