Deficient Autophagy in Microglia Aggravates Repeated Social Defeat Stress-Induced Social Avoidance

Figure 2

Repeated social defeat stress induced the expression of autophagic signaling in the prefrontal cortex. (a) Levels of the mRNA encoding the autophagic signaling marker Atg6 relative to those of S18. (b) Levels of the mRNA encoding the autophagic signaling marker Atg7 relative to those of S18. (c) Levels of the mRNA encoding the autophagic signaling marker Atg12 relative to those of S18. (d) Levels of the mRNA encoding the autophagic signaling marker Atg5 relative to those of S18. (e) Levels of the mRNA encoding the autophagic signaling marker Map1lc3b relative to those of S18. (f) Levels of the mRNA encoding the autophagic signaling marker p62 relative to those of S18. (g) Levels of the mRNA encoding the autophagic activator Fkbp5 relative to those of S18. Con: control mice; Sus: susceptible mice; Re: resilient mice. One-way ANOVA followed by Turkey’s post hoc test was applied to all comparisons (Con, ; Sus, ; Res, ). Data are presented as the . , , and vs. Con or Re.

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