Growth Hormone Increases BDNF and mTOR Expression in Specific Brain Regions after Photothrombotic Stroke in Mice

Figure 3

The effect of recombinant human growth factor (r-hGH) treatment poststroke on mammalian target of rapamycin (mTOR) in the hippocampus. (a) Representative blots of phosphorylated-mTOR (P-mTOR, active form), total-mTOR (T-mTOR), phosphorylated-p70s6-kinase (P-p70S6K), and total-p70s6k (T-p70S6K). (b) Data are presented as in Figure 2. We found a significant increase in T-p70S6K protein expression within the hippocampus in stroked mice treated with r-hGH (blue squares) compared with saline (red circles). , 2-tailed t-test.

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