Growth Hormone Increases BDNF and mTOR Expression in Specific Brain Regions after Photothrombotic Stroke in Mice

Figure 5

Correlation of uncleaved immature form of BDNF (pro-BDNF) with mammalian target of rapamycin (mTOR) and markers of neuroplasticity. Correlation of pro-BDNF, with T-mTOR (top panel), α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-receptor subunit GluR1 (marker of synaptic plasticity, second from top panel), NeuN (neuronal marker, third from top panel), and doublecortin (DCX, neuronal migration marker, bottom panel) in the peri-infarct region (a), hippocampus (b), and thalamus (c). Dataset GluR1, NeuN, and DCX was an excerpt from previous study [9, 28]. Correlations contain all three experimental groups, Sham+Saline (black crosses), Stroke+Saline (red circles), and Stroke+r-hGH (blue squares) and analyzed using Pearson’s correlation. Pearson’s and associated values for each correlation are reported on the corresponding graph.

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