Comparing the Expression of Genes Related to Serotonin (5-HT) in C57BL/6J Mice and Humans Based on Data Available at the Allen Mouse Brain Atlas and Allen Human Brain Atlas

Figure 4

Heatmaps of gene expression of serotonin system in donors. On the left, dendrogram with organization in two main groups (G1 and G2). The second group has two branches or trees. Below each heatmap a color representation of brain structures. The original heatmap for each donor in supplementary images. Group 1 is related to height expression in structures at cerebral cortex in general (white arrow). The hippocampal formation and together structures (dentate gyrus, CA1, CA2, and CA3) present low expression to compare with cortex but height expression in HTR1A gen and HTR4 and HTR7 (blue arrow). The orange arrow shows a group of genes related to inactivation MAOA, for example, and green arrow shows genes related to synthesis and storage. The column on the right has the convention of colors: (1) Frontal Lobe; (2) Insula; (3) Limbic Lobe; (4) Hippocampal Formation; (5) Occipital Lobe; (6) Parietal Lobe; (7) Temporal Lobe; (8) Amygdala; (9) Basal Ganglia; (10) Diencephalon; (11) Mesencephalon; (12) Hindbrain.