Effect of Different Doses and Times of FK506 on Different Areas of the Hippocampus in the Rat Model of Transient Global Cerebral Ischemia-Reperfusion

Figure 1

Photomicrographs of coronal sections of the hippocampus (dentate gyrus area) showed that in the control group (C), pyramidal cells (yellow arrows) showed normal morphology. In the I/R group, ischemia induces shrinkage, apoptotic, and fragmented neurons (Nissl bodies, red arrows). However, administered FK506 could significantly reduce Nissl bodies in E1-E5 groups (Nissl staining, 400× magnification, scale bar= 50 μm).