Neuroprotective Effects of Rosa damascena Extract against Aluminum Chloride-Induced Brain Damage in Rat Offspring

Table 1

Histopathological examination of necrosis and vacuolar degeneration in the cortex and hippocampus tissues of all groups.

	Cortex		Hippocampus
	Necrosis	Vacuolar degeneration	Necrosis	Vacuolar degeneration
Control	0.10 ± 0.10	0.10 ± 0.10	0.10 ± 0.10	0.10 ± 0.10
Sham	0.10 ± 0.10	0.10 ± 0.10	0.10 ± 0.10	0.10 ± 0.10
AL	1.10 ± 0.23^a,c	0.80 ± 0.20^a,c	1.10 ± 0.23^a,c	0.70 ± 0.15^a,b,c
AL + RDA 500	0.50 ± 0.17	0.30 ± 0.15	0.50 ± 0.17	0.20 ± 0.13
AL + RDA 1000	0.30 ± 0.15	0.20 ± 0.13	0.40 ± 0.16	0.20 ± 0.13
RDA 500	0.10 ± 0.10	0.10 ± 0.10	0.10 ± 0.10	0.10 ± 0.10
RDA 1000	0.11 ± 0.11	0.11 ± 0.11	0.11 ± 0.11	0.11 ± 0.11
value	0.001	0.010	0.001	0.011

Values are expressed as mean ± standard error. Significances of cortex and hippocampus lesions between groups (; Kruskal–Wallis test). ^aStatistically significant difference between the control and AL-treated groups. ^bStatistically significant difference between AL and RDA 500-treated groups. ^cStatistically significant difference between AL and RDA 1000-treated groups. N = 10.