Functional Role of P-Glycoprotein and Binding Protein Effect on the Placental Transfer of Lopinavir/Ritonavir in the Ex Vivo Human Perfusion Model

Table 2

Clearance index of lopinavir in the control phase (0–45 minutes) and Pgp placental expression for experiments during the control phase at physiological albumin concentrations (30–40 g/L).

Sample	1	2	3	4	5	6	7	8	9
Relative Pgp expression	1	3.1	3.14	3.59	0.68	2.71	3.38	0.74	0.31
ClI lopinavir	—	0	0	0.03	0	0	0	0	0.025

Pgp: P-glycoprotein, ClI: clearance index. Sample 1: control cell line R7. Samples 2–9: relative expression to sample 1 expression.