Strategies for Molecularly Enhanced Chemotherapy to Achieve Synthetic Lethality in Endometrial Tumors with Mutant p53
Figure 5
BIBF1120+paclitaxel modifies G2/M checkpoint controllers to induce transition into M phase. The effect of 1 μM BIBF1120, 14 nM paclitaxel, and combination treatment (24 h) on the posttranslational modification of cell cycle regulators was examined by Western blotting. *denotes slower-migrating CDC25C, indicative of activating phosphorylation.