Comparison of Expectant and Excisional/Ablative Management of Cervical Intraepithelial Neoplasia Grade 2 (CIN2) in the Era of HPV Testing

Table 1

Demographics, risk factors, and clinical results from colposcopy.

Variables	Initial conservative management (n: 172)	Initial excisional treatment (n: 155)	value
Age at Referral (median; range)	27; 21–43	28; 22–65	0.032
Smoking			0.362
Yes	50 (28.6%)	56 (35.9%)
No	114 (65.1%)	91 (58.3%)
Not available	11 (6.3%)	9 (5.8%)
Referral LBC results
Borderline changes (squamous/endocervical)	20 (11.4%)	14 (9.0%)	<0.001
Mild dyskariosis	94 (53.7%)	41 (26.3%)
Moderate dyskariosis	34 (19.4%)	44 (28.2%)
Severe dyskariosis	9 (5.1%)	44 (28.2%)
Clinical referrals (cytology not applicable)	17 (9.7%)	12 (7.7%)
Not available	1 (0.6%)	1 (0.6%)
Biopsy
Transformation zone			0.065
1	122 (69.7%)	89 (57.1%)
2	23 (13.1%)	29 (18.6%)
3	1 (0.6%)	4 (2.6%)
Not available	29 (16.6%)	34 (21.8%)
Colposcopy impression			<0.001
High-grade	37 (21.1%)	89 (57.1%)
Low-grade	124 (70.9%)	57 (36.5%)
Normal	3 (1.7%)	4 (2.6%)
Others	9 (5.1%)	6 (3.8%)
Not available	2 (1.1%)	0
Biopsy result			<0.001
CIN1-2	102 (58.3%)	41 (26.3%)
CIN2	73 (41.7%)	115 (73.7%)
LBC at biopsy (if done)			0.005
Borderline changes (squamous/endocervical)	7 (19.4%)	2 (5.1%)
Mild dyskariosis	9 (25.00%)	10 (25.6%)
Moderate dyskariosis	6 (16.7%)	11 (28.2%)
Severe dyskariosis	0	10 (25.6%)
Negative/Normal	14 (38.9%)	6 (15.4%)
HPV test at biopsy (if done)			0.022
Positive	44 (73.3%)	49 (94.2%)
Negative	16 (26.7%)	3 (5.8%)
Median follow-up (range)	23.4 months (1.9–55.9)	21.3 months (2.9–65.1)	0.982