Comparison of Expectant and Excisional/Ablative Management of Cervical Intraepithelial Neoplasia Grade 2 (CIN2) in the Era of HPV Testing

Table 3

Summary of characteristics of initial excision patients.

Variables	Total	LLETZ	Cold knife cone (CKC)	Diathermy ablation	value across 3 treatment groups
Number of patients	155	144 (92.9%)	5 (3.2%)	6 (3.9%)
Median age at referral in years (range)	28 (22–65)	28 (22–63)	42 (29–65)	24 (22–29)	0.003
Smoking
Yes	56 (100%)	51 (91.1%)	2 (3.6%)	3 (5.3%)	0.502
No	90 (100%)	85 (94.4%)	3 (3.3%)	2 (2.2%)
Not available	9 (100%)	8 (88.9%)	0	1 (11.1%)
Excisional margins
Endocervical margin					0.234
Not involved	132 (88.6%)	129 (89.6%)	3 (60%)	N/A
Involved	9 (6.0%)	8 (5.6%)	1 (20%)	N/A
Not available	8 (5.4%)	7 (4.8%)	1 (20%)
Ectocervical margin					>0.999
Not involved	102 (68.5%)	99 (68.8%)	3 (60%)	N/A
Involved	38 (25.5%)	37 (25.7%)	1 (20%)	N/A
Not available	9 (6.0%)	8 (5.5%)	1 (20%)
Radial Margin					>0.999
Not involved	117 (78.5%)	113 (78.5%)	4 (80%)	N/A
Involved	9 (6.0%)	9 (6.3%)	0	N/A
Not available	23 (15.4%)	22 (15.3%)	1 (20%)
Overall Margin					0.615
Not involved	93 (64.6%)	91 (65%)	2 (50%)	N/A
Involved	51 (45.4%)	49 (35%)	2 (50%)	N/A
TOC					0.049
Yes	123 (79.4%)	116 (80.6%)	3 (60%)	4 (66.7%)
No	32 (20.6%)	28 (19.4%)	2 (40%)	2 (33.3%)
Cure rates 6 months posttreatment	73.2% (90/123)	72.4% (84/116)	66.7% (2/3)	100% (4/4)
Overall cure rates (as of July 2019)	89.4% (110/123)	88.8% (103/116)	100% (3/3)	100% (4/4)	0.805
Median interval between referral and discharge (months) (range)	11.7 (2.9–74.8)	11.4 (2.9–74.8)	15.7 (8.8–40.2)	16.8 (13.5–29.6)	0.286
Median number of visits prior to discharge (range)	3 (2–8)	3 (2–8)	6 (3–8)	3 (3–4)	0.021