Melatonin Ameliorates Ovarian Hyperstimulation Syndrome (OHSS) through SESN2 Regulated Antiapoptosis

<div>The effect of melatonin on SESN2 levels of HUVEC and KGNs incubated with angiotensin II or H<sub>2</sub>O<sub>2</sub>. (a) The representative pictures of Western blotting of SESN2 and GAPDH in controls, 10 <i>μ</i>Μ melatonin or 1 <i>μ</i>M angiotensin II treated cells before incubation with 1 <i>μ</i>M angiotensin II in HUVECs; (b) the comparison of SESN2/GAPDH ratio in controls, angiotensin II, melatonin treated HUVECs; (c) the representative pictures of Western blotting of SESN2 and GAPDH in controls, 1 mΜ melatonin, 0.1 mM H<sub>2</sub>O<sub>2</sub>, 1 mΜ melatonin treated cells before incubation with 0.1 mM H<sub>2</sub>O<sub>2</sub> in KGNs; (d) the comparison of SESN2/GAPDH ratio in controls, melatonin, H<sub>2</sub>O<sub>2</sub>, treated KGNs. 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transform="matrix(.013,0,0,-0.013,55.606,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,61.846,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg>.</span> Ctrl: control; MLT: melatonin; Ang II: angiotensin II.</div>

Obstetrics and Gynecology International

fig3

Figure 3

Figure 3: Melatonin Ameliorates Ovarian Hyperstimulation Syndrome (OHSS) through SESN2 Regulated Antiapoptosis 