Age-Associated Molecular Changes in the Kidney in Aged Mice

Figure 2

Renal histopathology of the glomerulus and tubulointerstitial areas. Representative images of PAS ((a) original magnification 400×) and Trichrome stain ((b) original magnification 200×) from renal tissue as indicated. Quantitative assessment of the areas of extracellular matrix in the glomerulus (c) and the tubulointerstitial fibrosis (d) from indicated groups. There was increased mesangial area expansion in the 24 M group compared with other groups (10.1±1.19% versus 17.2±2%, 36.3±3.58%; **𝑃<0.01 versus 2 M), and significantly increased tubulointerstitial fibrosis in the 24 M group compared with other groups. (0.83±0.11% versus 0.87±0.07%, 15.9±1.99%; **𝑃<0.01 versus 2 M). Values are shown as mean ± SE.

(a)

(b)

(c)

(d)