Curcumin Induces Nrf2 Nuclear Translocation and Prevents Glomerular Hypertension, Hyperfiltration, Oxidant Stress, and the Decrease in Antioxidant Enzymes in 5/6 Nephrectomized Rats

Table 2

Effect of CUR and 5/6NX on mitochondrial oxygen consumption using malate/glutamate or succinate as substrates.

	Control	5/6NX	5/6NX + CUR	CUR
Malate/glutamate
State 3 (ngAO/min/mg)	193.9±19.2	197.3±7.3	187.9±12.8	188.8±17.5
State 4 (ngAO/min/mg)	72.6±8.7	77.7±6.4	69.7±4.3	72.9±7.1
RC	2.8±0.2	2.5±0.1	2.7±0.1	2.6±0.1
Uncoupled respiration (ngAO/min/mg)	233.1±28.0	238.3±22.7	225.3±19.5	247.1±28.3
ADP/O	2.2±0.4	1.8±0.1	1.9±0.1	2.1±0.2
Succinate
State 3 (ngAO/min/mg)	277.1±31.3	276.1±20.7	277.1±14.8	251.1±24.2
State 4 (ngAO/min/mg)	136.4±14.0	143.0±13.2	136.1±5.3	114.1±0.7
RC	2.0±0.1	2.0±0.1	2.0±0.1	2.2±0.1
Uncoupled respiration (ngAO/min/mg)	414.5±49.2	340.7±53.3	399.7±26.8	425.0±49.2
ADP/O	1.3±0.1	1.2±0.0	1.2±0.1	1.4±0.1

CUR: curcumin, 5/6NX: five-sixths nephrectomy, RC: respiratory control index, ngAO/min/mg: nanograms atoms oxygen/minute/milligrams protein. ADP/O: phosphorylation efficiency. Data represent mean ± SEM, 𝑛=7-15.