Oxidative Stress Contributes to Endothelial Dysfunction in Mouse Models of Hereditary Hemorrhagic Telangiectasia

Figure 2

ROS production is increased in tissues of mutant mice. H₂O₂ production was measured by Amplex red, to estimate tissue ROS production. H₂O₂ generation was increased in pulmonary, hepatic, and colonic tissues of (a) Eng ^+/− and (b) Alk1 ^+/− mice compared to those of corresponding wild-type mice. Cardiac ROS production was similar between mutant and control mice. *𝑃<0.05, **𝑃<0.01, and ***𝑃<0.001 versus +/+ mice; 𝑁=10–15/group for Eng mice and 7–20/group for Alk1 mice.

(a)

(b)