The Critical Role of Redox Homeostasis in Shikonin-Induced HL-60 Cell Differentiation via Unique Modulation of the Nrf2/ARE Pathway
Figure 4
The modulation of the Nrf2/ARE pathway downstream target genes in Shikonin-induced HL-60 cell differentiation. The mRNA expression levels of GPX and GR genes (a), GCLM and GCLC genes (c), and GST, CAT, and NQO1 genes (e) in HL-60 cells after 4 h of treatment with 0, 50, 75, or 100 ng/mL of Shikonin. The effects of the GSH modulators on the mRNA expression levels of GPX and GR genes (b), GCLM and GCLC genes (d), and GST, CAT, and NQO1 genes (f) in HL-60 cells treated with Shikonin for 4 h.
