Combination Therapy with Losartan and Pioglitazone Additively Reduces Renal Oxidative and Nitrative Stress Induced by Chronic High Fat, Sucrose, and Sodium Intake

Figure 2

Effects of losartan (L), pioglitazone (P), and their combination (L + P) on immunohistochemical staining of malondialdehyde (MDA) in glomeruli. Representative glomerular micrographs from the control (a), model (b), L-treated (c), P-treated (d), and L + P-treated (e) rats. Histogram (f) represents quantitative analysis (mean optical density) of MDA expression in each experimental group. Results are expressed as mean ± SD, 𝑛=6-7 per group. *𝑃<0.05 versus model group. ^†𝑃<0.05 versus control group. ^#𝑃<0.05 versus L + P group.

(a)

(b)

(c)

(d)

(e)

(f)