Combination Therapy with Losartan and Pioglitazone Additively Reduces Renal Oxidative and Nitrative Stress Induced by Chronic High Fat, Sucrose, and Sodium Intake

Figure 6

Effects of losartan (L), pioglitazone (P), and their combination (L + P) on expression of p47^phox in kidney. NADPH oxidase subunit p47^phox mRNA (a) and protein (b) expression was detected by RT-PCR and western blot analysis, respectively. Panels show representative bands and histograms represent optical density values normalized to the corresponding GAPDH or β-actin. Values are expressed as mean ± SD, 𝑛=4-5 per group. *𝑃<0.05 versus model group. ^†𝑃<0.05 versus control group. ^#𝑃<0.05 versus L + P group. C: control; M: model.

(a)

(b)