Dual Phases of Respiration Chain Defect-Augmented mROS-Mediated mCa2+ Stress during Oxidative Insult in Normal and ρ0 RBA1 Astrocytes
Figure 2
RC defect-augmented loss in cell viability during H2O2 stress as measured by the MTT assay. (a, b) Dose-dependent cytotoxic effect induced by H2O2 exposure in control (filled columns) and ρ 0 RBA1 astrocytes (empty columns); (a) time point for H2O2 exposure: 10 min and (b) 30 min. There were no statistically significant differences between the two groups in the cell viability at different concentration for 10 minutes () (a). 20 mM H2O2 caused a statistically significant loss in cell viability in ρ 0 astrocytes for 30 min when compared to control cells () (b). Data were expressed as mean values ± SE of four separate experiments. .
