The Amelioration of N-Acetyl-p-Benzoquinone Imine Toxicity by Ginsenoside Rg3: The Role of Nrf2-Mediated Detoxification and Mrp1/Mrp3 Transports

Figure 2

The protective effect of ginsenoside Rg3 on the NAPQI-induced toxicity in H4IIE cells. The cells were treated with the indicated concentrations of Rg3 or vehicle for 24 h. Then, the cells were incubated with NAPQI (400 μM) for 6 h. (a) ALT and (b) AST levels were monitored in the media to determine cytotoxicity. (c) GSH levels were determined in cell homogenates after exposure of the cells to NAPQI (400 μM) for 2 h after the cells had been pretreated or not pretreated with Rg3 for 24 h. All experiments were performed in quadruplicate. Each value represents the mean ± S.E. (**𝑃<0.01, ^∗𝑃<0.05, significantly different from control; ^#𝑃<0.05, significantly different from NAPQI).

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(b)

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