Effects of Paracetamol on NOS, COX, and CYP Activity and on Oxidative Stress in Healthy Male Subjects, Rat Hepatocytes, and Recombinant NOS
Figure 4
Effect of a 3 g single oral dose of paracetamol on plasma (a) and urine (c) nitrite, plasma (b) and urine (d) nitrate, and plasma arginine (Arg) and asymmetric dimethylarginine (ADMA) (e) in four healthy volunteers (time zero and baseline values are indicated by dashed lines). Data in plasma are shown as percentage changes of the baseline plasma nitrite concentrations (1.26, 3.04, 3.76, and 4.05 μM) and baseline plasma nitrate concentrations (37.3, 42.5, 26.8, and 52.9 μM), respectively. Data are shown as mean ± SEM. An asterisk indicates statistical significance () compared to the 0.5 h values.
