Oxidative Damage to Nucleic Acids and Benzo(a)pyrene-7,8-diol-9,10-epoxide-DNA Adducts and Chromosomal Aberration in Children with Psoriasis Repeatedly Exposed to Crude Coal Tar Ointment and UV Radiation

Table 3

Oxidative damage of DNA/RNA, BPDE-DNA adducts, and chromosomal aberrations in children treated by GT.

Oxidative damage of DNA and RNA^a		Significance of differences
Before GT	After GT
2557	2687
2008–2789)	2146–3238)
BPDE-DNA adducts^b		Significance of differences
Before GT	After GT
5.65	7.2
4.97–7.3)	5.35–7.9)
Chromosomal aberration in peripheral lymphocytes^c		Significance of differences
Before GT	After GT
Structurally aberrated cells
0.0	1.0
0.0-0.0)	0.0–1.0)
Numerically aberrated cells
0.0	0.0	NS
0.0-0.0)	0.0–1.0)
Total number of aberrated cells
0.0	1.0
0.0-0.0)	0.0–1.0)

^aOxidative damage of DNA and RNA is presented as the sum of three oxidized guanine species in serum: 8-hydroxy-2′-deoxyguanosine from DNA, 8-hydroxyguanosine from RNA, and 8-hydroxyguanine from either DNA or RNA. The levels are expressed as pg of the sum of oxidized guanine species per mL of serum. The average concentration is presented as median and lower-upper quartile because of nonnormal data distribution; : Wilcoxon matched-pairs test.
^bThe levels are expressed as ng of BPDE-DNA adducts per g of DNA and the average concentration is presented as median and lower-upper quartile because of nonnormal data distribution; : Wilcoxon matched-pairs test.
^cThe levels are expressed as percentage of structurally aberrated cells (SAC), numerically aberrated cells (NAC), and total number of aberrated cells (ABC). The average levels of aberration are presented as median and lower-upper quartile because of nonnormal data distribution; : Wilcoxon matched-pairs test; NS: nonsignificant difference.