Plasma Levels of Aminothiols, Nitrite, Nitrate, and Malondialdehyde in Myelodysplastic Syndromes in the Context of Clinical Outcomes and as a Consequence of Iron Overload

Table 1

Plasma levels of oxidative stress compounds in healthy donors and myelodysplastic patients (MDS). Data are expressed as means ± SD. Significant differences between MDS patients and healthy donors are marked with ∗. Data were analyzed using a two-tailed, two-sample Student’s t-test.

Analyzed compounds	Healthy donors (𝑛=23)	MDS patients (𝑛=61)
t-Cys (µM)	219 ± 14	284 ± 68***
t-Hcys (µM)	9.45 ± 0.63	14.50 ± 10.70***
t-CG (µM)	39.71 ± 4.86	48.80 ± 14.30**
t-GSH (µM)	9.07 ± 1.55	7.16 ± 3.59*
MDA (µM)	0.69 ± 0.11	0.82 ± 0.34
NO2^− (nM)	1149 ± 86	903 ± 215***
NO3^− (µM)	32.78 ± 10.33	32.80 ± 17.87
Ferritin (µg/L)	Ref. R.: 22–322	557.9 ± 4.0
Fe (µM)	Ref. R.: 7.2–29	26.15 ± 12.28
GGT (µkat/L)	Ref. R.: 0.14–0.8	0.60 ± 0.56

∗∗∗P < 0.001, **P < 0.005, *P < 0.05, total cysteine (t-Cys), total homocysteine (t-Hcys), total cysteinylglycine (t-CG), total glutathione (t-GSH), malondialdehyde (MDA), and gamma-glutamyltransferase (GGT).