Plasma Levels of Aminothiols, Nitrite, Nitrate, and Malondialdehyde in Myelodysplastic Syndromes in the Context of Clinical Outcomes and as a Consequence of Iron Overload

Table 2

Plasma levels of total, reduced, and oxidized forms of thiols in healthy donors and myelodysplastic patients (MDS). Data are expressed as means ± SD. Significant differences between MDS patients and healthy donors are marked with ∗. Data were analyzed using a two-tailed, two-sample Student’s t-test.

Analyzed compounds	Healthy donors (𝑛=23)	MDS patients (𝑛=61)
t-Cys (µM)	219 ± 14	284 ± 68***
red-Cys (µM)	4.06 ± 1.07	8.10 ± 3.46***
ox-Cys (µM)	215 ± 14	275 ± 67***
t-Hcys (µM)	9.45 ± 0.63	14.50 ± 10.70***
red-Hcys (µM)	0.03 ± 0.01	0.05 ± 0.07*
ox-Hcys (µM)	9.43 ± 0.63	14.45 ± 10.64***
t-CG (µM)	39.71 ± 4.86	48.8 ± 14.30**
red-CG (µM)	1.50 ± 0.51	3.35 ± 2.33***
ox-CG (µM)	38.21 ± 4.57	45.44 ± 12.72*
t-GSH (µM)	9.07 ± 1.55	7.16 ± 3.59*
red-GSH (µM)	0.39 ± 0.09	0.41 ± 0.39
ox-GSH (µM)	8.68 ± 1.48	6.74 ± 3.26*

∗∗∗P < 0.001, **P < 0.005, *P < 0.05, total cysteine (t-Cys), reduced cysteine (red-Cys), oxidised cysteine (ox-Cys), total homocysteine (t-Hcys), reduced homocysteine (red-Hcys), oxidised homocysteine (ox-Hcys), total cysteinylglycine (t-CG), reduced cysteinylglycine (red-CG), oxidised cysteinylglycine (ox-CG), total glutathione (t-GSH), reduced glutathione (red-GSH), and oxidised glutathione (ox-GSH).