Plasma Levels of Aminothiols, Nitrite, Nitrate, and Malondialdehyde in Myelodysplastic Syndromes in the Context of Clinical Outcomes and as a Consequence of Iron Overload
Table 4
Oxidative stress parameters in the control group (0) and four myelodysplastic syndromes subgroups (1–4). Values are shown as means ± SD. Data were analyzed by ANOVA, and P values are shown for significantly differing parameters.
Analyzed compounds
Analyzed groups
P value
0
1
2
3
4
t-Cys (µM)
219 ± 14
300 ± 57
284 ± 71
274 ± 56
268 ± 90
t-Hcys (µM)
9.45 ± 0.63
11.73 ± 4.87
17.12 ± 14.51
13.50 ± 3.17
11.38 ± 4.75
t-CG (µM)
39.71 ± 4.86
56.09 ± 18.81
47.54 ± 11.41
49.70 ± 8.15
40.59 ± 14.95
*0.032
t-GSH (µM)
9.07 ± 1.55
8.36 ± 4.27
6.83 ± 2.88
7.25 ± 4.89
6.26 ± 3.22
MDA (µM)
0.70 ± 0.12
0.99 ± 0.51
0.74 ± 0.25
0.92 ± 0.31
0.71 ± 0.15
(nM)
1185 ± 93
960 ± 275
890 ± 225
827 ± 108
945 ± 173
*0.021
(µM)
34.80 ± 11.16
33.14 ± 13.87
37.47 ± 20.32
29.29 ± 18.91
20.78 ± 6.91
Ferritin (µg/L)
Ref. R.: 22–322
1569 ± 2
330 ± 6
1681 ± 2
250 ± 3
Fe (µM)
Ref. R.: 7.2–29
38.19 ± 9.13
25.23 ± 13.15
29.44 ± 7.20
19.51 ± 10.1
GGT (µkat/L)
Ref. R.: 0.14–0.8
0.75 ± 0.77
0.70 ± 0.71
0.60 ± 0.17
0.42 ± 0.27
Total cysteine (t-Cys), total homocysteine (t-Hcys), total cysteinylglycine (t-CG), total glutathione (t-GSH), malondialdehyde (MDA), and gamma-glutamyltransferase (GGT).
