Aging Leads to Elevation of O-GlcNAcylation and Disruption of Mitochondrial Homeostasis in Retina

Figure 6

Effects of treatments increasing protein O-GlcNAc modification on mitochondrial function in ARPE-19 cells. ARPE cells were treated with PUGNAc or D-GlcNAc separately for 24 h. Mitochondrial oxygen consumption capacity (a) and ROS content (b) was analyzed. The values are the means ± S.E.M from three independent experiments. ^∗𝑃<0.05 and ^∗∗𝑃<0.01 as calculated by one-way ANOVA.

(a)

(b)