Hemin Attenuates Cisplatin-Induced Acute Renal Injury in Male Rats
Figure 3
Electron micrographs of kidney of CP-treated rats. (a) Renal glomerulus with thickened GBM (++), capillary lumens are obliterated by endocapillary hypercellularity and hypertrophy (arrows). Note also fusion of secondary foot processes (FP) and mesangial hypercellularity (arrowheads). (b) Proximal convoluted tubule cell containing large cytoplasmic vacuoles (V), clusters of deformed mitochondria (arrows), numerous lysosomal bodies (Ly), and lamellar (myeloid) body (Mb). Observe nucleus (N) with condensed chromatin pattern. Arrowhead points to partial destruction of the brush border. (c) Abnormal distal tubular cells with few organelles. Arrow indicates apoptotic cell.
