Hemin Attenuates Cisplatin-Induced Acute Renal Injury in Male Rats
Figure 4
Electron micrographs of kidney of CP plus hemin-treated rats. (a) Glomerulus with nearly regular foot processes (arrows) and limited mesangial matrix (*). Arrowhead indicates a resting platelet inside glomerular capillary vessel. Capillary endothelium (E) and slight thickening of GBM (++) are indicated. (b) Proximal convoluted tubule cell showing loss of large vacuolar structures; only small vacuoles (V) are seen beneath the intact brush border microvilli (BBM). Nucleus (N), mitochondria (M), and lysosomes are of normal morphology. (c) Dilated distal tubule with normal cellular ultrastructure. Detachment/loss of pleomorphic microvilli is indicated by arrow.
