SIRT1 Functions as an Important Regulator of Estrogen-Mediated Cardiomyocyte Protection in Angiotensin II-Induced Heart Hypertrophy

Figure 3

Estrogen attenuates Angiotensin II-induced oxidative stress and cell apoptosis. (a) The average data of ROS fluorescence intensity relative ratio in the NRVMs of Con, AngII, AngII + E2, and AngII + E2 + ICI by DHE staining (-6, ). (b)-(c) Representative TUNEL staining and the average data of the NRVMs of the 4 groups of NRVMs (, 8 , ). (d) The average data of ROS fluorescence intensity relative ratio in the 4 groups of NRVMs assayed by DHE staining (, 8 , ). (e) The average data of TUNEL positive ratio of Con, AngII, AngII + E2, and AngII + E2 + Nic NRVMs (, , , ).

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