SIRT1 Functions as an Important Regulator of Estrogen-Mediated Cardiomyocyte Protection in Angiotensin II-Induced Heart Hypertrophy

Figure 4

SIRT1 overexpression blocks cardiomyocyte hypertrophy and oxidative stress-induced apoptosis in cardiomyocytes. (a)-(b) Western blot of SIRT1 protein expression and the average data of 30 m.o.i. of control vector adenovirus (Vector-Ad) and 30 m.o.i. of SIRT1 adenovirus infected NRVMs (, ). (c)–(e) The average data of protein and DNA relative ratio (c), the average data of cell surface area (d), and TUNEL staining average data (e) in the NRVMs infected by Vector-Ad or SIRT1-Ad and treated with AngII or AngII + niacinamide (NIC) (, , ).

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