Oxidative Stress Activates the Transcription Factors FoxO 1a and FoxO 3a in the Hippocampus of Rats Exposed to Low Doses of Ozone
Figure 3
Effect of ozone exposure on cyclin D2. (a) Photomicrographs of cyclin D2-positive cells (red) in the dentate gyrus (DG) of rat hippocampi exposed to ozone for different periods of time (7, 15, 30, 60, and 90 days) or exposed to ozone-free air (control). An increase from 7 days to 90 days of ozone exposure was observed. This protein shows nuclear localization from 30 days to 90 days of ozone exposure. Insets are a zoom from selected areas in the same picture. (b) A representative western blot illustrating changes throughout the treatment. The graph shows densitometry values presented as the mean ± SD (∗) ().
