The Magnolia Bioactive Constituent 4-O-Methylhonokiol Protects against High-Fat Diet-Induced Obesity and Systemic Insulin Resistance in Mice

Figure 2

Effects of MH on body-weight and food intake in mice fed by normal fat diet (ND) or by high-fat- diet (HFD). Male C57/BL/6J mice at 8 weeks of age were fed either by ND (10% kcal as fat) or by HFD (60% kcal as fat) with vehicle (0.5% ethanol), BL-153 (5 mg/kg body weight), or MH (0.5 or 1 mg/kg body-weight) for 24 weeks. (a) Time-course body-weight change; (b) body-weight gain at the end of experiment; (c) average food intake for 12 weeks. Data were presented as means ± SEM (𝑛=5). A:  𝑃<0.05 versus ND.

(a)

(b)

(c)