The Magnolia Bioactive Constituent 4-O-Methylhonokiol Protects against High-Fat Diet-Induced Obesity and Systemic Insulin Resistance in Mice

Figure 6

Effects of MH on the glucose tolerance, blood glucose, and plasma insulin level in mice fed with ND or with HFD for 24 weeks. (a) Blood glucose was measured using a glucometer. (b) Plasma insulin level was measured by kit. (c) HOMA-IR was calculated by using both fasting glucose and insulin as follows: HOMA-IR = glucose × insulin/405, where glucose is given in mg/dl and insulin is given in 𝜇U/mL. (d) Blood glucose concentration during glucose tolerance test (2 g/kg) following fasting 6 h in mice. (e) The area under the curve (AUC) for glucose tolerance was calculated using the trapezoidal rule. Data were presented as means ± SEM (𝑛=5). A: 𝑃<0.05 versus ND; B: 𝑃<0.05 versus HFD.

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