LPS Induces Occludin Dysregulation in Cerebral Microvascular Endothelial Cells via MAPK Signaling and Augmenting MMP-2 Levels

Figure 1

Cell viability. hCMEC/D3 were treated with different concentrations of LPS (0, 1, 10, 50, and 100 μg/mL), SB203580 (0, 0.19, 0.38, 3.85, 7.69, and 19.23 μg/mL), or SP600125 (0, 0.11, 0.22, 2.20, 4.40, and 11.00 μg/mL) for 24 h. Cell viability was not affected by LPS, SB203580, and SP600125 concentrations under 10, 7.69, and 0.22 μg/mL, respectively. The results are the mean ± SEM (). , versus control.

(a)

(b)

(c)