LPS Induces Occludin Dysregulation in Cerebral Microvascular Endothelial Cells via MAPK Signaling and Augmenting MMP-2 Levels

Figure 2

Effects of LPS on TJs expression. hCMEC/D3 were exposed to different concentrations of LPS (0, 1, 10, 50, and 100 μg/mL) for 24 h. Protein levels of occludin and ZO-1 were detected by western blot. The relative intensities of occludin and ZO-1 were calculated as a ratio of target protein to GAPDH. Quantification of occludin (a) and ZO-1 (b) expressions is shown as a bar graph. Results are the mean ± SEM (). , versus control.

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(b)