LPS Induces Occludin Dysregulation in Cerebral Microvascular Endothelial Cells via MAPK Signaling and Augmenting MMP-2 Levels

Figure 5

p38MAPK and JNK signaling pathways involved in LPS-induced alterations in MMP-2 mRNA and protein levels. Following treatment with inhibitors of p38MAPK and JNK signaling pathways, MMP-2 mRNA and protein levels were detected by qRT-PCR and ELISA, respectively. Results are mean ± SEM (). , versus control. ^### versus LPS.

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