LPS Induces Occludin Dysregulation in Cerebral Microvascular Endothelial Cells via MAPK Signaling and Augmenting MMP-2 Levels

Figure 6

Effects of MMP-2 on LPS-induced occludin expression. hCMEC/D3 were pretreated with inhibitors of total MMPs (doxycycline hyclate 1 μg/mL) or MMP-2 (SB-3CT 13.9 nmol/L) for 1 h prior to 24-hour LPS treatment (10 μg/mL). Occludin protein levels were detected by western blot. Data are expressed as mean ± SEM (). versus control. ^### versus LPS.