Glucose Oxidase Induces Cellular Senescence in Immortal Renal Cells through ILK by Downregulating Klotho Gene Expression

Figure 7

Proposed integrative mechanisms involved in cellular senescence induced by chronic oxidative stress in renal cells. Oxidative stress increases ILK activity and expression, which in turn reduces Klotho gene expression. Cells with reduced levels of Klotho are less protected from oxidative stress and undergo senescence.