Nitric Oxide Regulates Neurogenesis in the Hippocampus following Seizures

Table 1

NO increased NSC proliferation following treatment with KA.

Days	iNOS^+/+ saline		iNOS^+/+ KA		iNOS^−/− saline		iNOS^−/− KA
	Mean	SEM	Mean	SEM	Mean	SEM	Mean	SEM
1	16,82	0,91	9,39	1,04	11,31	2,86	7,72	1,43
2	23,13	1,31	33,23	1,86	12,10	1,33	13,35	3,87
3	24,45	1,77	63,3	1,36	16,71	4,05	25,64	0,53
5	26,32	1,12	82,6	5,87	15,58	0,96	18,36	1,99
7	21,60	0,49	82,4	3,44	20,08	0,61	87,0	8,39
14	21,71	1,77	37,4	1,99	17,15	1,38	27,33	2,16

Evaluation of cell proliferation in the subgranular zone (SGZ) of iNOS^+/+ versus iNOS^−/− mice, at several time points after SE, assessed by BrdU incorporation. Following seizure induction, there is a time-dependent increase in cell proliferation in iNOS^+/+ animals, peaking at day 5. In iNOS^−/− mice, only 7 days after SE the number of BrdU+ cells significantly increases in the SGZ. At least 3 surviving animals were used for each experimental group. Data are expressed as means ± SEM. Two-factor ANOVA: = 3 to 5, < 0.01 and < 0.001, significantly different from iNOS^+/+ saline; < 0.001, significantly different from iNOS^−/− saline.