Increased Clearance of Reactive Aldehydes and Damaged Proteins in Hypertension-Induced Compensated Cardiac Hypertrophy: Impact of Exercise Training

Figure 4

Hypertensive rats present increased cardiac activity of aldehyde dehydrogenase 2 and proteasome during compensated hypertrophy. Aldehyde dehydrogenase 2 (ALDH2) activity (a), ALDH2 protein levels (b), proteasome chymotrypsin-like activity (c), 20S proteasome α5/α7, β1, β5, and β7 protein levels (d), and E3 ubiquitin ligases Atrogin (e) and MuRF-1 (f) protein levels and their representative blots (g) in heart lysate from control (normotensive), sedentary spontaneously hypertensive rats (SHR), and swimming-trained SHR (SHRt). Protein expression was normalized by GAPDH. Data are presented as mean ± SEM. versus control. versus SHR.

(a)

(b)

(c)

(d)

(e)

(f)

(g)