Mitochondrial Retrograde Signaling: Triggers, Pathways, and Outcomes

Figure 1

Simplified scheme of the RTG-dependent retrograde signaling pathway. In Saccharomyces cerevisiae this pathway depends on three proteins. Rtg1 and Rtg3 form a transcription factor that translocates to the nucleus when the pathway is activated. In the nucleus, Rtg1 and Rtg3 control the expression of a set of genes that code for mitochondrial proteins. Rtg2 is an activator of the pathway that allows the nuclear translocation of Rtg1 and Rtg3.