hCLOCK Causes Rho-Kinase-Mediated Endothelial Dysfunction and NF-κB-Mediated Inflammatory Responses

Figure 6

Proposed signaling pathway of the hCLOCK-induced hypoxia response. hCLOCK is the primary inducer of the hypoxia response, leading to ROS production, which in turn induces the RhoA and NF-κB signaling pathways and upregulates key downstream inflammatory effectors IL-6 and COX-2.