Kinetic Modeling Reveals the Roles of Reactive Oxygen Species Scavenging and DNA Repair Processes in Shaping the Dose-Response Curve of KBrO₃-Induced DNA Damage

Figure 5

Simulations with an additional SSB repair (SSBR) mechanism. (a) An additional SSB repair mechanism was included in the model. (b) SSB repair rate constant was set to be slower than BER. In this case the dose-response of 8-OH-dG was highly sublinear, while the SSB dose-response had linear behavior as in our base model. (c) SSB repair rate constant was set to be similar to the BER rate constant. Dose-response dependence of 8-OH-dG and that of SSB (inset) both had some level of sublinearity.

(a)

(b) Slow SSB Repair

(c) Efficient SSB Repair