Antioxidant Capacity of “Mexican Arnica” Heterotheca inuloides Cass Natural Products and Some Derivatives: Their Anti-Inflammatory Evaluation and Effect on C. elegans Life Span
Table 2
Scavenging capacity of H. inuloides metabolites on hypochlorous acid, hydroxyl radical, peroxide, superoxide anion, and singlet oxygen (IC50).
Compound
Scavenging capacity IC50μM
HOCl
OH•
H2O2
1O2
2
69.1 ± 8.8*
133.4 ± 32.6
270 ± 2.7*
114.6 ± 13.9*
880.4 ± 55.4*
3
202.3 ± 21.9*
545.4 ± 23.0*
422 ± 8.0*
105 ± 7.2*
538.9 ± 58.6
4
203.5 ± 23.9*
607.9 ± 33.5*
536 ± 14*
148 ± 13.0*
112.4 ± 29.3*
7
68.1 ± 5.77*
161.2 ± 27.2
201 ± 6.7*
20 ± 0.27*
209.7 ± 44.5*
8
133.9 ± 9.0*
187.1 ± 44.6
252 ± 6.5*
70.4 ± 3.3*
237.8 ± 43.1*
9
60.0 ± 5.2*
139.5 ± 1.1
154 ± 6.3*
12.2 ± 0.22
314.4 ± 15.8
13
106.1 ± 4.4*
523.8 ± 20.4*
322 ± 21.0*
181.5 ± 29.8*
697 ± 187.0*
15
110.0 ± 15.8*
435.78 ± 82.0*
434.5 ± 23.3*
244.1 ± 78.0*
478.6 ± 44.7*
Reference compound
Ascorbic acid
DMTU
Pyruvate
NDGA
GSH
278.6 ± 16.7
131.5 ± 3.6
32.2 ± 1.7
11.6 ± 0.13
471 ± 77
Data represent the mean ± SE of the three independent assays. The results were analyzed by ANOVA. The Dunnet’s multiple comparison test was used to compare outcomes between experimental and control group. * < 0.05 versus reference compound.
