[Retracted] Biomolecular Modulation of Neurodegenerative Events during Ageing

Figure 2

Modifications to nuclear DNA (TUNEL assay). (a) Section of the optic nerve head of a young rat with no obvious abnormalities (6 months, negative control). (b) Section of the optic nerve head of an untreated aged rat (24 months, positive control). Nuclei with degraded DNA showed greater fluorescence than nuclei in which the degenerative process was absent. (c) Section of the optic nerve head of an aged rat after oral supplementation with α-lipoic acid (ALA) and superoxide dismutase (SOD) (24 months, positive control). In this case, the assay was not positive, due to reduced degradation of DNA caused by the cytoprotective effect of the antioxidants.

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