Partial Oxygen Pressure Affects the Expression of Prognostic Biomarkers HIF-1 Alpha, Ki67, and CK20 in the Microenvironment of Colorectal Cancer Tissue

Figure 6

The association between pO₂ levels and tissue size of CRC and/or protein levels of biomarkers in different-size CRC tissues. (a) The correlation between pO₂ levels and tissue size of CRC. (b) The correlation between pO₂ levels and the protein level of HIF-1 alpha in different-size CRC tissues. (c) The correlation between pO₂ levels and the protein level of CK20 in different-size CRC tissues. (d) The correlation between pO₂ levels and the protein level of Ki67 in different-size CRC tissues. Small-size CRC tissues (<300 mm³, ); middle-size CRC tissues (301–600 mm³, ); big-size CRC tissues (601–900 mm³, ); super-size CRC tissues (>900 mm³, ). Statistical values were measured by using a test for Spearman’s rank correlation. If the values were between −1 and −0.5, there was a strong negative relation. If the values were between 0.5 and 1, there was a strong positive relation.

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